Pathologists still do not understand the pathogenesis, that is, the mechanism for the development of novel coronavirus infection, despite the fact that the epidemic has developed views on the causes of death from COVID-19. According to “Dr. Peter”, this was stated by the head of the Center for infectious disease City hospital. Botkin, head of the Department of pathomorphology of the Almazov Centre Professor Vsevolod Zinserling. According to him, to explain the appearance of a picture which the pathologists can see in an autopsy “very approximately”.
“the Morphological pattern is, first and foremost, lungs, but are observed and the frequent defeat of organs and tissues outside of them, in particular, intestine, brain, adrenal glands, kidneys, lymph nodes, myocardium and spleen. Almost all have comorbidities background, often, diabetes mellitus and obesity, there is a combination of HIV and tuberculosis.”
the Medic stressed that comorbidity, that is, a condition in which the patient has two or more chronic diseases, pathogenetically related to each other and occur at the same time, plays a very important role.
“In some cases on purely formal grounds we can assume with high probability that couId adversely affect the course of the disease. We have little information on ischemic heart disease. Not very many, but there are data, including those published in reputable international medical journals, that the virus can affect the adrenal glands, leading to endocrine insufficiency, which on the background of the serious condition of the patients is identified. We have evidence that the virus affects the organs of immunogenesis, on the one hand leading to immune deficiency, and on the other hand inducing autoimmune destruction,” — said Vsevolod Zinserling.
in addition, according to the doctor, a serious question for consideration — how long the virus SARS-CoV-2 is stored in the organizkite and how it can cause chronic infection.
the Professor also commented on the attempts to compare COVID-19 and the flu. He noted that the coronavirus and influenza are not only at the level of organism, tissue and cell destruction. However, there are similarities.
“But we can’t talk about the flu in General. Morphological manifestations of infection vary greatly depending on the variant of the flu virus, he added. In influenza 2016 appeared features similar to the microscopic changes in cowhide. Was discovered a new effect — zitoprotectivei. This means that the cells of the ciliated epithelium of the bronchi did not immediately die, the infection is getting longer infectious period is extended, the active period of the disease lasts up to three weeks.”
Vsevolod Zinserling also noticed that almost all deaths from coronavirus is thrombosis, wound severity, and at the macro – and microcirculatory level in the arteries and veins. However, he said, the role of thrombosis in the mechanism of death is different for everyone.
the Anosmia, i.e. the loss of smell and taste, the pathologist explained the possible lesions of the Central nervous system, olfactory of the brain.
Earlier, the pulmonologist said not today in the hands of physicians are no precise tools for the treatment of pneumonia caused by the novel coronavirus infection. Disease different flows in different people, the same treatment may help one patient and not produce the desired effect in another.
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